David Sinclair

Genetics Professor, Aging Research Expert, Biotech Entrepreneur

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Boston, MA, USA
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David Sinclair Biography

David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics, Blavatnik Institute, and co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School. He is renowned for his research on why we age and strategies to mitigate its effects. Sinclair obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney, in 1995, and conducted postdoctoral research at M.I.T. with Dr. Leonard Guarente, where he co-discovered a cause of aging in yeast and the role of Sir2 in epigenetic changes driven by genome instability and aging. In 1999, he joined Harvard Medical School, focusing on the role of protective enzymes called sirtuins, which respond to changing NAD+ levels, exercise, and caloric restriction (CR). His lab was the first to identify a role for NAD biosynthesis in lifespan regulation and demonstrated that sirtuins facilitate the benefits of CR in mammals. They also identified the first small molecules that activate SIRT1 (STACs).

The Sinclair lab has expanded its research to include epigenetic changes as a driver of aging and the use of reprogramming factors to reset the age of cells and tissues. In 2020, his team demonstrated that aging can be safely reversed in animal models to cure blindness. Sinclair is the New York Times bestselling author of "Lifespan: Why We Age and Why We Don't Have To" (2019), has authored over 200 scientific papers, and is a co-inventor on more than 50 patents. He serves as co-chief editor of the scientific journal Aging, and has co-founded several biotechnology companies, including MetroBiotech, EdenRoc Sciences, Tally Health, and Life Biosciences, focusing on aging, vaccines, diabetes, infectious diseases, immunity, and cancer.

Sinclair has received more than 40 awards, including the Australian Medical Research Medal, the Irving Wright Award, and the NIH Director’s Pioneer Award. He was named one of TIME magazine's “100 most influential people in the world” and among the “Top 50 people in Healthcare.” In 2018, he was appointed an Officer of the Order of Australia (AO) for his contributions to scientific communication and national security. In 2022, he co-founded Fully Aligned LLC, a company aimed at enhancing mind and body well-being. He also hosts the popular health and fitness podcast "Lifespan, with David Sinclair."

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Speaker profile last updated by AAE Talent Team on 05/04/2024.

David Sinclair Videos

  • David Sinclair: "Lifespan: Why We Age and Why We Don't Have To ...
    David Sinclair, professor of genetics at Harvard Medical School, discusses his new book "Lifespan", which distills his cutting-edge research ...
  • This Harvard Professor Explains the Secret to Aging in Reverse ...
    This Harvard Professor Explains the Secret to Aging in Reverse | David Sinclair on Health Theory. Tom Bilyeu. Loading... Unsubscribe from ...

David Sinclair Books

  • Lifespan: Why We Age_and Why We Don't Have To
    Lifespan: Why We Age_and Why We Don't Have To

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  • What topics does David Sinclair speak about?

    David Sinclair is a keynote speaker and industry expert whose speaking topics include Aging, Authors, Biology, Education, Health, Professors, Research & Exploration, TED.
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David Sinclair is a keynote speaker and industry expert who speaks on a wide range of topics . The estimated speaking fee range to book David Sinclair for your event is available upon request. David Sinclair generally travels from Boston, MA, USA and can be booked for (private) corporate events, personal appearances, keynote speeches, or other performances. Similar motivational celebrity speakers are Joan Lunden, Sir Richard Branson, Jeffrey Kluger, Dr. Gregory Stock and Michael Rogers. Contact All American Speakers for ratings, reviews, videos and information on scheduling David Sinclair for an upcoming live or virtual event.

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