Carl June

Director of the Center for Cellular Immunotherapies & Translational Research Translational Research, Abramson Cancer Center

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Philadelphia, PA, USA
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Carl June Biography

Carl June, MD, is the Richard W. Vague Professor in Immunotherapy in the Department of Pathology and Laboratory Medicine. His work led to the development and commercialization of tisagenlecleucel, the first FDA-approved gene therapy. He is most well known for his research into T cell therapies for the treatment of cancer.

He is currently director of the Center for Cellular Immunotherapies and director of Translational Research in the Abramson Cancer Center of the University of Pennsylvania, and is an investigator of the Abramson Family Cancer Research Institute.

June is a graduate of the Naval Academy in Annapolis and Baylor College of Medicine in Houston, 1979. He had graduate training in immunology and malaria with Dr. Paul-Henri Lambert at the World Health Organization, Geneva, Switzerland in 1978 and 1979, and post-doctoral training in transplantation biology with E. Donnell Thomas and John Hansen at the Fred Hutchinson Cancer Research Center in Seattle from 1983 to 1986. He is board certified in Internal Medicine and Medical Oncology.

He maintains a research laboratory that studies various mechanisms of lymphocyte activation that relate to immune tolerance and adoptive immunotherapy for cancer and chronic infection. In 2011, his research team published findings, which represented the first successful and sustained demonstration of the use of gene transfer therapy to treat cancer. Clinical trials utilizing this approach, in which patients are treated with genetically engineered versions of their own T-cells, are now underway for adults with chronic lymphocytic leukemia and adults and children with acute lymphoblastic leukemia.

Early results in that group show that 90 percent of patients respond to the therapy, and more recently, trials of this approach have begun for patients with other blood cancers and solid tumors including pancreatic cancer, mesothelioma and the brain cancer glioblastoma. In 2014, it became the first personalized cellular therapy for the treatment of cancer therapy to receive the U.S. Food and Drug Administration’s prestigious Breakthrough Therapy designation.

He has published more than 350 manuscripts and is the recipient of numerous prizes and honors, including election to the Institute of Medicine in 2012, the William B. Coley award, the Richard V. Smalley Memorial Award from the Society for Immunotherapy of Cancer, the AACR-CRI Lloyd J. Old Award in Cancer Immunology, the Hamdan Award for Medical Research Excellence and the Paul Ehrlich and Ludwig Darmstaedter Prize. In 2014, he was elected to the American Academy of Arts and Sciences.

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Speaker profile last updated by AAE Talent Team on 04/10/2024.

Carl June Videos

  • Curing Leukemia with Immunologist Carl June | Google Zeitgeist
    Google Zeitgeist is a collection of talks by people who are changing the world. Hear entrepreneurs, CEOs, storytellers, scientists, and dreamers...
  • Curing Cancer: The Philadelphia Award and Dr. Carl June
    This year the prestigious Philadelphia Award honored Penn Medicine's Dr. Carl June for his breakthrough work in curing leukemia in a number of...
  • Carl H. June, MD - Celebration of Science
    "Quantum Leap: Brakes-off T-Cells - Better Engineered for the Surface Target You Always Wanted to Annihilate but Never Could Until Now"

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  • What topics does Carl June speak about?

    Carl June is a keynote speaker and industry expert whose speaking topics include Business, Business Leadership, Creativity, Genetics, Health, Innovation, Medicine, Public Health, Science.
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    Carl June generally travels from Philadelphia, PA, USA, but can be booked for private corporate events, personal appearances, keynote speeches, or other performances. For more details, please contact an AAE Booking agent.
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Carl June is a keynote speaker and industry expert who speaks on a wide range of topics . The estimated speaking fee range to book Carl June for your event is $20,000 - $30,000. Carl June generally travels from Philadelphia, PA, USA and can be booked for (private) corporate events, personal appearances, keynote speeches, or other performances. Similar motivational celebrity speakers are Toby Cosgrove, Dr. Joel Selanikio, Dr. Francis Collins, Seth Berkley and Scott Harrison. Contact All American Speakers for ratings, reviews, videos and information on scheduling Carl June for an upcoming live or virtual event.

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